两种色胺受体。
Two kinds of tryptamine receptor.
作者信息
GADDUM J H, PICARELLI Z P
出版信息
Br J Pharmacol Chemother. 1957 Sep;12(3):323-8. doi: 10.1111/j.1476-5381.1957.tb00142.x.
Abstract
There are two kinds of tryptamine receptor in the guinea-pig ileum, namely the M receptors which can be blocked with morphine and the D receptors which can be blocked with dibenzyline. Atropine, an atropine-like drug, cocaine, and methadone inhibit effects due to the M receptors, even after dibenzyline, but have no additional effect after morphine. Lysergic acid diethylamide, dihydroergotamine and 5-benzyloxygramine inhibit effects due to the D receptors, even after morphine, but have no additional effect after dibenzyline. The M receptors are probably in the nervous tissue and the D receptors are probably in the muscles.
摘要
豚鼠回肠中有两种色胺受体，即可被吗啡阻断的M受体和可被双苄胺阻断的D受体。阿托品、一种类似阿托品的药物、可卡因和美沙酮即使在使用双苄胺后也能抑制由M受体引起的效应，但在使用吗啡后无额外作用。麦角酸二乙胺、二氢麦角胺和5-苄氧基格拉明即使在使用吗啡后也能抑制由D受体引起的效应，但在使用双苄胺后无额外作用。M受体可能存在于神经组织中，而D受体可能存在于肌肉中。
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