Krug H, Ebeling K
Zentralbl Gynakol. 1976;98(7):410-7.
By flow microfluorometry the DNA distribution curve of the cell nuclei of 39 adnex tumors, mainly ovarian carcinomas, was measured. 47% of the malignant tumor cell populations were diploid, the other ones were heteroploid (i.e. polyploid, tetraploid, aneuploid stem lines). Heteroploid tumors had the worse prognosis. In 8 cases effusions were analysed (7 ascites, 1 pleura). It is possible to diagnose a malignant tumor from effussion fluid by impulse cytophotometry. But in one case a great difference was found between the primary tumor and the ascites fluid, which only shows the DNA distribution of an irritative effusion. The value of impulse cytophotometry for clinical purposes is discussed.
通过流动微荧光测定法，测量了39例附件肿瘤（主要为卵巢癌）细胞核的DNA分布曲线。47%的恶性肿瘤细胞群体为二倍体，其他为异倍体（即多倍体、四倍体、非整倍体干细胞系）。异倍体肿瘤预后较差。分析了8例积液（7例腹水，1例胸水）。通过脉冲细胞光度法有可能从积液中诊断出恶性肿瘤。但有1例发现原发肿瘤与腹水之间存在很大差异，腹水仅显示刺激性积液的DNA分布。讨论了脉冲细胞光度法在临床应用中的价值。
