Sugita S, Shen K Z, North R A
Vollum Institute, Oregon Health Sciences, University, Portland 97201.
Neuron. 1992 Jan;8(1):199-203. doi: 10.1016/0896-6273(92)90121-s.
A fast excitatory synaptic potential mediated by 5-hydroxytryptamine (5-HT) was recorded in rat lateral amygdala neurons in brain slices. The synaptic potential has brief duration (tens of milliseconds), is mimicked by 5-HT, is potentiated by a 5-HT uptake inhibitor, and is blocked by selective 5-HT3 receptor antagonists. The underlying synaptic current reversed polarity at about 0 mV. This is an example of fast neurotransmission in the mammalian brain mediated by an amine rather than an amino acid. The antiemetic, anxiolytic, and perhaps antipsychotic actions of 5-HT3 antagonists might result from blockade of such synapses.
在脑片的大鼠外侧杏仁核神经元中记录到了由5-羟色胺（5-HT）介导的快速兴奋性突触电位。该突触电位持续时间短暂（几十毫秒），可被5-HT模拟，被5-HT摄取抑制剂增强，并被选择性5-HT3受体拮抗剂阻断。潜在的突触电流在约0 mV处反转极性。这是哺乳动物脑中由胺而非氨基酸介导的快速神经传递的一个例子。5-HT3拮抗剂的止吐、抗焦虑以及可能的抗精神病作用可能是由于此类突触被阻断所致。
