通过中和转化生长因子β抗体来控制成人伤口的瘢痕形成

Control of scarring in adult wounds by neutralising antibody to transforming growth factor beta.

作者信息

Shah M, Foreman D M, Ferguson M W

机构信息

Department of Cell and Structural Biology, School of Biological Sciences, University of Manchester, UK.

出版信息

Lancet. 1992 Jan 25;339(8787):213-4. doi: 10.1016/0140-6736(92)90009-r.

DOI:10.1016/0140-6736(92)90009-r

PMID:1346175

Abstract

Adult wounds heal with scar-tissue formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. We injected the margins of healing dermal wounds in adult rats with neutralising antibody (NA) to transforming growth factor-beta (TGF-beta). All control wounds (irrelevant antibody, or TGF-beta, or no injection) healed with scarring, whereas the NA-treated wounds healed without scar-tissue formation; NA-treated wounds had fewer macrophages and blood vessels, lower collagen and fibronectin contents, but identical tensile strength and more normal dermal architecture than the other wounds. Early manipulation of the concentrations of selected cytokines may be a new approach to the control of scarring.

摘要

成年伤口愈合会形成瘢痕组织，而胎儿伤口愈合时无瘢痕形成，且炎症和细胞因子反应较轻。我们给成年大鼠正在愈合的皮肤伤口边缘注射了转化生长因子-β（TGF-β）中和抗体（NA）。所有对照伤口（无关抗体、TGF-β或未注射）均形成瘢痕愈合，而经NA处理的伤口愈合时未形成瘢痕组织；经NA处理的伤口巨噬细胞和血管较少，胶原蛋白和纤连蛋白含量较低，但与其他伤口相比，其抗张强度相同，真皮结构更正常。早期调控特定细胞因子的浓度可能是控制瘢痕形成的一种新方法。