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视黄酸对培养的大鼠肝细胞中过氧化物酶体β-氧化基因的诱导作用。

Induction of peroxisomal beta-oxidation genes by retinoic acid in cultured rat hepatocytes.

作者信息

Hertz R, Bar-Tana J

机构信息

Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

出版信息

Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):41-3. doi: 10.1042/bj2810041.

DOI:10.1042/bj2810041
PMID:1346245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1130637/
Abstract

Retinoic acid is reported here to induce peroxisomal beta-oxidation activities in cultured rat hepatocytes, with a concomitant increase in respective peroxisomal mRNAs. The concentrations of retinoic acid required for inducing liver peroxisomal acyl-CoA oxidase were similar to those required for inducing liver transglutaminase. A putative 5'-flanking response element for retinoic acid may be found within the enhancer region involved in the induction of peroxisomal genes by xenobiotic amphipathic carboxylates.

摘要

本文报道视黄酸可诱导培养的大鼠肝细胞中的过氧化物酶体β-氧化活性，同时相应的过氧化物酶体mRNA也会增加。诱导肝脏过氧化物酶体酰基辅酶A氧化酶所需的视黄酸浓度与诱导肝脏转谷氨酰胺酶所需的浓度相似。在异源生物双亲性羧酸盐诱导过氧化物酶体基因的增强子区域内可能存在一个假定的视黄酸5'-侧翼反应元件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cbc/1130637/ce5085b406db/biochemj00144-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cbc/1130637/ce5085b406db/biochemj00144-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cbc/1130637/ce5085b406db/biochemj00144-0050-a.jpg

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Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):41-3. doi: 10.1042/bj2810041.
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本文引用的文献

1
Evaluation of selected hypolipidemic agents for the induction of peroxisomal enzymes and peroxisome proliferation in the rat liver.对大鼠肝脏中过氧化物酶体酶诱导及过氧化物酶体增殖的选定降血脂药物的评估。
Hum Toxicol. 1983 Jan;2(1):27-48. doi: 10.1177/096032718300200103.
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Cloning of cDNAs specifying vitamin A-responsive human keratins.
Proc Natl Acad Sci U S A. 1984 Jul;81(14):4321-5. doi: 10.1073/pnas.81.14.4321.
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High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.大鼠肝脏实质细胞分离的高效制备：生化与精细结构研究
脂肪酸和类视黄醇通过激活过氧化物酶体增殖物激活受体-视黄醇X受体异二聚体来控制脂质代谢。
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4. doi: 10.1073/pnas.90.6.2160.
4
Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.过氧化物酶体增殖物激活受体与视黄酸X受体的相互作用。
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1440-4. doi: 10.1073/pnas.90.4.1440.
5
Cellular binding proteins for fatty acids and retinoids: similar or specialized functions?脂肪酸和类视黄醇的细胞结合蛋白：功能相似还是具有特异性？
Mol Cell Biochem. 1993;123(1-2):191-202. doi: 10.1007/BF01076492.
6
Dehydroepiandrosterone 3 beta-sulphate is an endogenous activator of the peroxisome-proliferation pathway: induction of cytochrome P-450 4A and acyl-CoA oxidase mRNAs in primary rat hepatocyte culture and inhibitory effects of Ca(2+)-channel blockers.硫酸脱氢表雄酮是过氧化物酶体增殖途径的内源性激活剂：原代大鼠肝细胞培养中细胞色素P-450 4A和酰基辅酶A氧化酶mRNA的诱导以及钙通道阻滞剂的抑制作用。
Biochem J. 1994 Aug 1;301 ( Pt 3)(Pt 3):753-8. doi: 10.1042/bj3010753.
7
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.通过9-顺式视黄酸与其受体的异源二聚体形成，9-顺式视黄酸信号通路与过氧化物酶体增殖物信号通路的汇聚。
Nature. 1992 Aug 27;358(6389):771-4. doi: 10.1038/358771a0.
J Cell Biol. 1969 Dec;43(3):506-20. doi: 10.1083/jcb.43.3.506.
4
Molecular cloning and nucleotide sequence of the cDNA for rat peroxisomal enoyl-CoA: hydratase-3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme.大鼠过氧化物酶体烯酰辅酶A水合酶-3-羟酰基辅酶A脱氢酶双功能酶cDNA的分子克隆及核苷酸序列
J Biol Chem. 1985 Jul 25;260(15):8905-10.
5
Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.过氧化物酶体增殖剂对大鼠肝脏中过氧化物酶体脂肪酰辅酶A氧化酶和烯酰辅酶A水合酶/3-羟酰辅酶A脱氢酶的转录调控
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1747-51. doi: 10.1073/pnas.83.6.1747.
6
Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver catalase.大鼠肝脏过氧化氢酶cDNA的完整核苷酸序列及推导的氨基酸序列
Proc Natl Acad Sci U S A. 1986 Jan;83(2):313-7. doi: 10.1073/pnas.83.2.313.
7
Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver. A mechanistic inter-relationship.
Biochem Pharmacol. 1988 Apr 1;37(7):1193-201. doi: 10.1016/0006-2952(88)90770-8.
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The induction of liver peroxisomal proliferation by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16).β,β'-甲基取代的十六烷二酸（MEDICA 16）对肝脏过氧化物酶体增殖的诱导作用
Biochem Pharmacol. 1988 Oct 1;37(19):3571-7. doi: 10.1016/0006-2952(88)90387-5.
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Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase.大鼠过氧化物酶体3-酮酰基辅酶A硫解酶cDNA的结构分析
J Biol Chem. 1987 Jun 15;262(17):8151-8.
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Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase.大鼠酰基辅酶A氧化酶的cDNA完整核苷酸序列及预测的氨基酸序列
J Biol Chem. 1987 Jun 15;262(17):8131-7.