Reiser K, Whitcomb C, Robinson K, MacKenzie M R
Am J Ment Defic. 1976 May;80(6):613-9.
Individuals with Down's syndrome are thought to have abnormalities of immune function. Studies to quantify the number of peripheral blood T and B lymphocytes and serum immunoglobulins in 12 individuals and 12 sex and age matched control subjects were performed. Hepatitis B antigen and antihyroglobulin antibodies as markers of possible immune dysfunction were determined. The numbers of circulating T and B cells, and the level of serum immunoglobulins in children with Down's syndrome did not differ from nonretarded control children. Circulating hepatitis B antigen and antihyroglobulin antibodies were not present. These studies indicated that quantitative abnormalities of T and B cells are not present in children with Down's syndrome. The data did not exclude the existence of qualitative abnormalities.
唐氏综合征患者被认为存在免疫功能异常。对12名唐氏综合征患者以及12名年龄和性别匹配的对照受试者进行了外周血T淋巴细胞和B淋巴细胞数量以及血清免疫球蛋白的定量研究。检测了乙肝抗原和抗甲状腺球蛋白抗体，以作为可能存在免疫功能障碍的标志物。唐氏综合征患儿的循环T细胞和B细胞数量以及血清免疫球蛋白水平与发育正常的对照儿童并无差异。未检测到循环乙肝抗原和抗甲状腺球蛋白抗体。这些研究表明，唐氏综合征患儿不存在T细胞和B细胞的定量异常。这些数据并未排除定性异常的存在。
