唐氏综合征中的细胞介导免疫缺陷：白细胞介素-2产生正常，但T细胞亚群比例倒置。
Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets.
作者信息
Karttunen R, Nurmi T, Ilonen J, Surcel H M
出版信息
Clin Exp Immunol. 1984 Feb;55(2):257-63.
Abstract
To get more information on the mechanism of cell-mediated immunodeficiency associated with Down's syndrome, 18 patients were studied for PHA-induced lymphocyte transformation and interleukin-2 (IL-2) production. A normal amount of IL-2 was produced although half of the patients showed decreased blast transformation. T cell subpopulations were studied in some patients with decreased and with normal blast transformation. All studied patients with decreased blast transformation had inverted helper/suppressor T cell ratio.
摘要
为了获取更多关于与唐氏综合征相关的细胞介导免疫缺陷机制的信息，对18名患者进行了PHA诱导的淋巴细胞转化和白细胞介素-2（IL-2）产生的研究。尽管一半的患者显示出母细胞转化减少，但仍产生了正常量的IL-2。对一些母细胞转化减少和正常的患者进行了T细胞亚群研究。所有母细胞转化减少的研究患者均有辅助/抑制性T细胞比例倒置的情况。
相似文献
1
Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets.唐氏综合征中的细胞介导免疫缺陷：白细胞介素-2产生正常，但T细胞亚群比例倒置。
Clin Exp Immunol. 1984 Feb;55(2):257-63.
2
[Evaluation of the immune system in Down's syndrome patients].[唐氏综合征患者免疫系统的评估]
Allergol Immunopathol (Madr). 1984 Jan-Feb;12(1):45-52.
3
Monoclonal antibody defined T cell subsets and autologous mixed lymphocyte reaction in Down's syndrome.唐氏综合征中由单克隆抗体定义的T细胞亚群与自体混合淋巴细胞反应
Clin Exp Immunol. 1983 Jul;53(1):25-30.
4
[Characteristics of cellular immunity in multiple sclerosis].[多发性硬化症中的细胞免疫特征]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(2):35-41.
5
6
Interleukin-2 production and response by helper T-cell subsets in man.人类辅助性T细胞亚群的白细胞介素-2产生及反应
Immunology. 1988 Sep;65(1):81-5.
7
Impaired production of interleukins in patients with cell-mediated immunodeficiencies.细胞介导免疫缺陷患者白细胞介素产生受损。
Clin Exp Immunol. 1983 Feb;51(2):338-44.
8
Immunoregulatory CD4+ CD45R+ suppressor/inducer T lymphocyte subsets and impaired cell-mediated immunity in patients with Down's syndrome.唐氏综合征患者中免疫调节性CD4+ CD45R+抑制/诱导性T淋巴细胞亚群及细胞介导免疫受损
Clin Exp Immunol. 1990 Jan;79(1):67-71. doi: 10.1111/j.1365-2249.1990.tb05128.x.
9
[T-cell subsets, lymphocyte proliferation and IL-2 level in patients with anterior uveitis].[前葡萄膜炎患者的T细胞亚群、淋巴细胞增殖及白细胞介素-2水平]
Zhonghua Yan Ke Za Zhi. 1990 Jul;26(4):232-4.
引用本文的文献
1
Down syndrome, accelerated aging and immunosenescence.唐氏综合征、加速衰老与免疫衰老。
Semin Immunopathol. 2020 Oct;42(5):635-645. doi: 10.1007/s00281-020-00804-1. Epub 2020 Jul 23.
2
The first case of isolated facial cutanenous leishmaniasis in a Down syndrome infant: a case report and review of the literature.唐氏综合征婴儿首例孤立性面部皮肤利什曼病：病例报告及文献复习
Cases J. 2009 Jan 6;2(1):13. doi: 10.1186/1757-1626-2-13.
3
Interleukin 2 production in whole blood culture: a rapid test of immunity to Francisella tularensis.全血培养中白细胞介素2的产生：一种对土拉弗朗西斯菌免疫的快速检测方法。
J Clin Microbiol. 1985 Aug;22(2):318-9. doi: 10.1128/jcm.22.2.318-319.1985.
4
Interleukin 2 activity in chronic liver disease and the effect of in vitro alpha-interferon.慢性肝病中的白细胞介素2活性及体外α干扰素的作用
Clin Exp Immunol. 1986 Mar;63(3):541-8.
5
Stem cell deficiencies and thymic abnormalities in fetal mouse trisomy 16.胎儿小鼠16三体中的干细胞缺陷和胸腺异常。
J Exp Med. 1985 Aug 1;162(2):695-712. doi: 10.1084/jem.162.2.695.
6
Interleukin 2 and gamma interferon production, interleukin 2 receptor expression, and DNA synthesis induced by tularemia antigen in vitro after natural infection or vaccination.自然感染或接种疫苗后，土拉菌病抗原在体外诱导产生白细胞介素2和γ干扰素、白细胞介素2受体表达及DNA合成。
J Clin Microbiol. 1987 Jun;25(6):1074-8. doi: 10.1128/jcm.25.6.1074-1078.1987.
7
Cell-mediated cytotoxicity in Down syndrome: impairment of allogeneic mixed lymphocyte reaction, NK and NK-like activities.唐氏综合征中的细胞介导细胞毒性：同种异体混合淋巴细胞反应、自然杀伤细胞及自然杀伤样细胞活性受损。
Eur J Pediatr. 1988 Oct;148(1):53-7. doi: 10.1007/BF00441815.
8
T cell response to anti-CD3 antibody in Down's syndrome.唐氏综合征中T细胞对抗CD3抗体的反应。
Arch Dis Child. 1987 Nov;62(11):1148-51. doi: 10.1136/adc.62.11.1148.
9
Analysis of impaired in vitro immunoglobulin synthesis in rheumatoid arthritis.类风湿关节炎中体外免疫球蛋白合成受损的分析。
Ann Rheum Dis. 1990 Jul;49(7):507-11. doi: 10.1136/ard.49.7.507.
10
Immunoregulatory CD4+ CD45R+ suppressor/inducer T lymphocyte subsets and impaired cell-mediated immunity in patients with Down's syndrome.唐氏综合征患者中免疫调节性CD4+ CD45R+抑制/诱导性T淋巴细胞亚群及细胞介导免疫受损
Clin Exp Immunol. 1990 Jan;79(1):67-71. doi: 10.1111/j.1365-2249.1990.tb05128.x.
本文引用的文献
1
Derangements of immunoglobulin levels, phytohemagglutinin responsiveness and T and B cell markers in Down's syndrome at different ages.不同年龄段唐氏综合征患者免疫球蛋白水平、植物血凝素反应性及T和B细胞标志物的紊乱情况。
Eur J Immunol. 1975 Sep;5(9):600-3. doi: 10.1002/eji.1830050904.
2
Role of T cells and adherent cells in age-related decline in murine interleukin 2 production.T细胞和黏附细胞在小鼠白细胞介素2产生的年龄相关性下降中的作用。
J Immunol. 1982 Dec;129(6):2426-30.
3
Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.系统性红斑狼疮患者培养淋巴细胞白细胞介素 -2 的产生及反应降低。
J Clin Invest. 1982 Jun;69(6):1388-92. doi: 10.1172/jci110579.
4
5
Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.衰老的免疫学研究。老年人淋巴细胞产生T细胞生长因子的能力及其对T细胞生长因子反应性的降低。
J Clin Invest. 1981 Apr;67(4):937-42. doi: 10.1172/jci110143.
6
Impaired production of interleukins in patients with cell-mediated immunodeficiencies.细胞介导免疫缺陷患者白细胞介素产生受损。
Clin Exp Immunol. 1983 Feb;51(2):338-44.
7
T-lymphocyte subpopulations in relation to immunosuppression in measles and varicella.麻疹和水痘中与免疫抑制相关的T淋巴细胞亚群
Infect Immun. 1983 Jan;39(1):29-37. doi: 10.1128/iai.39.1.29-37.1983.
8
Down's syndrome as a model disease.唐氏综合征作为一种典型疾病。
Arch Intern Med. 1982 Mar;142(3):462-4.
9
Enumeration of T lymphocyte subsets by monoclonal antibodies in young and aged humans.用单克隆抗体对年轻人和老年人的T淋巴细胞亚群进行计数。
J Immunol. 1981 Nov;127(5):2086-8.
10
Altered cellular immune functions in patients with Down's syndrome.唐氏综合征患者的细胞免疫功能改变。
Am J Dis Child. 1981 Mar;135(3):251-5. doi: 10.1001/archpedi.1981.02130270043015.
Zotero 插件