鸡CD4+和CD8+细胞的频率。劳斯肉瘤病毒感染的遗传控制及影响。

Frequency of chicken CD4+ and CD8+ cells. Genetic control and effect of Rous sarcoma virus infection.

作者信息

Hála K, Böck G, Sgonc R, Schulmannová J, Tempelis C H, Vainio O, Kemmler G

机构信息

Institute for General and Experimental Pathology, University of Innsbruck, Austria.

出版信息

Scand J Immunol. 1992 Feb;35(2):237-45. doi: 10.1111/j.1365-3083.1992.tb02856.x.

DOI:10.1111/j.1365-3083.1992.tb02856.x

PMID:1346728

Abstract

In chickens from congenic inbred lines CB and CC that differ only in the major histocompatibility complex (MHC), we observed significantly different percentages of CD4+ and CD8+ cells in peripheral blood lymphocytes (PBL) and spleen. Positive cells were detected by indirect immunofluorescence test as analysed by flow cytometry. In both PBL and spleen cell suspensions, the number of CD4+ cells was significantly higher in CB than in CC chickens, whereas in CC birds there was a higher percentage of CD8+ cells than in CB. These statistically significant differences were under the MHC control. We found no statistically significant influence of regressions or progression of Rous sarcoma virus-induced tumours on the percentage of peripheral T cells and on the interleukin-2 production in vitro.

摘要

在仅主要组织相容性复合体（MHC）不同的同基因近交系CB和CC鸡中，我们观察到外周血淋巴细胞（PBL）和脾脏中CD4⁺和CD8⁺细胞的百分比存在显著差异。通过间接免疫荧光试验检测阳性细胞，并经流式细胞术分析。在PBL和脾细胞悬液中，CB鸡的CD4⁺细胞数量显著高于CC鸡，而CC鸡的CD8⁺细胞百分比高于CB鸡。这些统计学上的显著差异受MHC控制。我们发现劳斯肉瘤病毒诱导的肿瘤的消退或进展对外周T细胞百分比和体外白细胞介素-2的产生没有统计学上的显著影响。