An in vitro gas equilibration method for determination of chemical partition coefficients in fish.

Hoffman A D, Bertelsen S L, Gargas M L

United States Environmental Protection Agency, Environmental Research Laboratory--Duluth, MN.

Comp Biochem Physiol A Comp Physiol. 1992;101(1):47-51. doi: 10.1016/0300-9629(92)90626-2.

Abstract

A gas equilibration method for the determination of in vitro chemical partition coefficients in mammals was adapted for use with fish. 2. In vitro blood: water and tissue: blood partition coefficients were determined for three chlorinated ethanes in rainbow trout (Oncorhynchus mykiss). 3. In vitro partition coefficients accurately predicted chemical concentrations in tissues of exposed trout.

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