一种模拟神经节苷脂的鼠/人嵌合抗独特型抗体的制备与表征
Production and characterization of a murine/human chimeric anti-idiotype antibody that mimics ganglioside.
作者信息
Hastings A, Morrison S L, Kanda S, Saxton R E, Irie R F
机构信息
Department of Surgical Oncology, School of Medicine, University of California, Los Angeles 90024.
出版信息
Cancer Res. 1992 Apr 1;52(7):1681-6.
PMID:1348012
Abstract
The VL and VH from a murine anti-idiotypic antibody that mimics ganglioside have been cloned, sequenced, and expressed as a chimeric mouse/human IgG1 antibody. The chimeric antibody retained a binding specificity indistinguishable from the original murine antibody. The VH was a member of Vgam 3.8 family. The sequences are discussed in terms of ways in which proteins may mimic ganglioside epitopes.
摘要
一种模拟神经节苷脂的鼠抗独特型抗体的VL和VH已被克隆、测序，并表达为嵌合型小鼠/人IgG1抗体。该嵌合抗体保留了与原始鼠抗体无法区分的结合特异性。VH是Vgam 3.8家族的成员。本文根据蛋白质模拟神经节苷脂表位的方式对这些序列进行了讨论。
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