Pospísil J, Perlík F
Department of Clinical Pharmacology, Charles University of Prague, Czechoslovakia.
Int J Clin Pharmacol Ther Toxicol. 1992 Jan;30(1):24-8.
The present in vivo study elucidated the effect of other commonly comedicated drugs on the phenytoin (PHT) Scatchard binding parameters. Specimens of 150 epileptic patients chronically treated with anticonvulsant drugs were analyzed. The results of covariance analysis suggest that phenobarbitone, ethosuximide, diazepam and folic acid do not alter binding of PHT to serum albumin. The contribution of carbamazepine and medazepam to the free fraction of PHT (decrease of about 0.4%) and/or Scatchard binding capacity (increase of about 1/3) is ambiguous and not statistically significant at the p less than 0.05 level. On the contrary, we found a statistically significant decrease of PHT binding in patients comedicated with valproic acid (VPA) and primidone (PRM). The decrease of about 25% in binding capacity evoked an increase of about 1% (VPA), and 1.5% (PRM), respectively in PHT free fraction.
本体内研究阐明了其他常用合并用药对苯妥英（PHT）Scatchard结合参数的影响。分析了150例长期接受抗惊厥药物治疗的癫痫患者的样本。协方差分析结果表明，苯巴比妥、乙琥胺、地西泮和叶酸不会改变PHT与血清白蛋白的结合。卡马西平和美达西泮对PHT游离分数（降低约0.4%）和/或Scatchard结合能力（增加约1/3）的影响不明确，在p小于0.05水平时无统计学意义。相反，我们发现合并使用丙戊酸（VPA）和扑米酮（PRM）的患者中PHT结合有统计学意义的降低。结合能力降低约25%分别导致PHT游离分数增加约1%（VPA）和1.5%（PRM）。
