DAVENPORT F M, HENNESSY A V
J Exp Med. 1957 Dec 1;106(6):835-50. doi: 10.1084/jem.106.6.835.
The antibody orienting effects of prior infections with antigenic variants of influenza viruses were confirmed by studies with monovalent adjuvant vaccines and with polyvalent aqueous and adjuvant preparations. In either case, the predominant antibody response was of a "booster" type, directed against the major antigens of strains of original infection. It was shown that vaccination with appropriate strains, selected as antigenic prototypes, could orient or predetermine subsequent antibody response upon revaccination. Moreover, the effects of exposure by vaccination were found to be durable and to constitute a foundation upon which future antibody dividends could be accumulated. As a result, it seems feasible to induce by vaccination a more lasting broad composite antibody protection against influenza if appropriate preparations and schedules are used.
通过使用单价佐剂疫苗以及多价水性制剂和佐剂制剂进行研究,证实了先前感染流感病毒抗原变体所产生的抗体定向效应。在这两种情况下,主要的抗体反应均为“加强”型,针对原始感染毒株的主要抗原。结果表明,选用作为抗原原型的合适毒株进行疫苗接种,可以在再次接种时定向或预先确定后续的抗体反应。此外,发现疫苗接种所产生的暴露效应具有持久性,并构成了未来积累抗体收益的基础。因此,如果使用合适的制剂和接种程序,通过疫苗接种诱导针对流感的更持久广泛的复合抗体保护似乎是可行的。