Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA.
Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA.
Trends Immunol. 2018 Jan;39(1):70-79. doi: 10.1016/j.it.2017.08.003. Epub 2017 Aug 31.
Antibody responses are essential for protection against influenza virus infection. Humans are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that immune history influences the magnitude and quality of the antibody response. The 'original antigenic sin' concept refers to the impact of the first influenza virus variant encounter on lifelong immunity. Although this model has been challenged since its discovery, past exposure, and likely one's first exposure, clearly affects the epitopes targeted in subsequent responses. Understanding how previous exposure to influenza virus shapes antibody responses to vaccination and infection is critical, especially with the prospect of future pandemics and for the effective development of a universal influenza vaccine.
抗体反应对于预防流感病毒感染至关重要。人类一生中会接触到多种流感病毒，很明显，免疫史会影响抗体反应的强度和质量。“原始抗原性失误”的概念是指首次遇到流感病毒变异株对终身免疫的影响。尽管自发现以来，该模型一直受到挑战，但过去的暴露，很可能是首次暴露，显然会影响随后反应中针对的表位。了解先前接触流感病毒如何影响疫苗接种和感染后的抗体反应至关重要，特别是对于未来大流行的预防以及通用流感疫苗的有效开发。
