Kai H, Isohama Y, Takaki K, Oda Y, Murahara K, Takahama K, Miyata T
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Eur J Pharmacol. 1992 Feb 25;212(1):101-3. doi: 10.1016/0014-2999(92)90079-j.
A primary culture of rat type II pneumocytes was used for the pharmacological and functional characterization of beta-adrenoceptor subtypes. The beta-adrenoceptor agonists, isoprenaline, dobutamine and procaterol concentration dependently increased the secretion of phosphatidylcholine. These effects were attenuated by propranolol. The effect of dobutamine was attenuated by atenolol, and that of procaterol by ICI 118,551. Isoprenaline-induced secretion was attenuated by the combination of the two blockers but not by each one alone. In conclusion, both beta 1- and beta 2-adrenoceptor subtypes mediate phosphatidylcholine secretion in rat type II pneumocytes.
大鼠II型肺细胞的原代培养用于β-肾上腺素能受体亚型的药理学和功能特性研究。β-肾上腺素能受体激动剂异丙肾上腺素、多巴酚丁胺和丙卡特罗浓度依赖性地增加磷脂酰胆碱的分泌。这些作用被普萘洛尔减弱。多巴酚丁胺的作用被阿替洛尔减弱，丙卡特罗的作用被ICI 118,551减弱。异丙肾上腺素诱导的分泌被两种阻滞剂联合减弱，但单独使用每种阻滞剂时未减弱。总之，β1-和β2-肾上腺素能受体亚型均介导大鼠II型肺细胞中磷脂酰胆碱的分泌。
