麦角酸二乙酰胺、5-羟色胺及相关化合物对肝吸虫（肝片吸虫）的作用。
The effect of lysergic acid diethylamide, 5-hydroxytryptamine, and related compounds on the liver fluke, Fasciola hepatica.
作者信息
MANSOUR T E
出版信息
Br J Pharmacol Chemother. 1957 Dec;12(4):406-9. doi: 10.1111/j.1476-5381.1957.tb00156.x.
Abstract
The rhythmical activity of the liver fluke, Fasciola hepatica, was stimulated by 5-hydroxytryptamine and by lysergic acid diethylamide at very low concentrations. The effect was peripheral and was not mediated through the central ganglion. Other amines also stimulated rhythmical activity, the most potent being the indolamines.Bromolysergic acid diethylamide, and other analogues such as yohimbine, harmine, and dopamine depressed rhythmical movement and antagonized the stimulant action of 5-hydroxytryptamine and lysergic acid diethylamide. Evidence which suggests the presence of tryptamine receptors in the trematode is discussed.
摘要
极低浓度的5-羟色胺和麦角酸二乙胺可刺激肝片吸虫（Fasciola hepatica）的节律性活动。这种作用是外周性的，并非通过中枢神经节介导。其他胺类也能刺激节律性活动，其中最有效的是吲哚胺类。溴麦角酸二乙胺以及其他类似物，如育亨宾、骆驼蓬碱和多巴胺，会抑制节律性运动，并拮抗5-羟色胺和麦角酸二乙胺的刺激作用。文中讨论了提示吸虫中存在色胺受体的证据。
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