Gotfredsen C F
Diabetologia. 1976 Aug;12(4):339-42. doi: 10.1007/BF00420977.
In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, and glisoxepide, which were all alike in terms of the relationship between first and second phases of insulin release.
在离体灌注大鼠胰腺中，在灌注缓冲液中基础葡萄糖水平为1mg/ml的情况下对多种磺脲类药物进行了测试，发现它们会引起双相胰岛素反应。新型强效磺脲类药物诺伏克司476以及格列本脲在胰岛素释放的第一相和第二相之间的关系方面与甲苯磺丁脲、格列波脲、格列吡嗪和格列索脲在性质上有所不同，而后几种药物在这方面表现相似。
