苏联患者不同肿瘤中ERBB - 2（HER - 2/NEU）癌基因的扩增
Amplification of ERBB-2 (HER-2/NEU) oncogene in different neoplasms of patients from USSR.
作者信息
Knyazev P G, Imyanitov E N, Chernitca O I, Nikiforova I F, Hanson K P
机构信息
N.N. Petrov Research Institute of Oncology, Leningrad, USSR.
出版信息
Oncology. 1992;49(2):162-5. doi: 10.1159/000227032.
203 tumor specimens from 175 patients were studied. Amplification of ERBB-2 was detected in 14 out of 63 (22%) cases of breast carcinoma, in 1 out of 23 patients with ovarian cancers, in 1 out of 19 cases of colon carcinoma and in 1 out of 27 patients with thyroid cancer. We failed to find more than one copy of ERBB-2 in 34 patients with lung cancers, 6 with sarcomas and 3 with melanomas. There was tendency toward correlation between ERBB-2 amplification and lymph node involvement in patients with breast carcinoma. Thus, the oncogene ERBB-2 is often amplified in human tumors, but breast cancer is characterized by an especially high frequency of ERBB-2 amplification.
对175例患者的203份肿瘤标本进行了研究。在63例乳腺癌病例中有14例（22%）检测到ERBB-2扩增，23例卵巢癌患者中有1例，19例结肠癌病例中有1例，27例甲状腺癌患者中有1例。在34例肺癌患者、6例肉瘤患者和3例黑色素瘤患者中，未发现ERBB-2有多于一个拷贝。乳腺癌患者中，ERBB-2扩增与淋巴结受累之间存在相关趋势。因此，癌基因ERBB-2在人类肿瘤中常发生扩增，但乳腺癌的特点是ERBB-2扩增频率特别高。
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