Reynolds G P
Department of Biomedical Science, University of Sheffield, UK.
Trends Pharmacol Sci. 1992 Mar;13(3):116-21. doi: 10.1016/0165-6147(92)90041-4.
Despite its efficacy in many cases, the drug treatment of schizophrenia remains problematic. A substantial proportion of patients do not improve, and many others suffer from unpleasant side-effects. In this review, Gavin Reynolds describes the new approaches to antipsychotic drug development that attempt to address these problems, and relates some of these approaches to growing evidence for neuronal pathology in the brain in schizophrenia.
尽管药物治疗在许多情况下有效，但精神分裂症的药物治疗仍然存在问题。相当一部分患者病情没有改善，还有许多患者遭受不良副作用的困扰。在这篇综述中，加文·雷诺兹描述了抗精神病药物开发的新方法，这些方法试图解决这些问题，并将其中一些方法与精神分裂症患者大脑中神经元病理学的越来越多的证据联系起来。
