Paterson S
Department Forensic Medicine and Toxicology, Charing Cross and Westminster Medical School, London.
Br J Clin Pharmacol. 1992 Apr;33(4):449-50. doi: 10.1111/j.1365-2125.1992.tb04066.x.
A single oral dose of Diconal (dipipanone HCl 10 mg, cyclizine HCl 30 mg) was given to six volunteers. The mean peak plasma dipipanone concentration was 29 ng ml-1, the time to peak plasma concentration was 1-2 h, the mean elimination half-life was 3.5 h and the mean AUC was 156 ng ml-1 min. Less than 1% of the dose was excreted in urine unchanged over 24 h.
给6名志愿者单次口服一剂双醋二苯甲吗啉（盐酸二苯哌己酮10毫克，盐酸赛克利嗪30毫克）。血浆中二苯哌己酮的平均峰浓度为29纳克/毫升，达峰时间为1至2小时，平均消除半衰期为3.5小时，平均曲线下面积为156纳克/毫升·分钟。24小时内，经尿液排泄的未代谢药物剂量不到1%。
