Lélek I
Rofo. 1976 Sep;125(3):259-61.
Experiments injecting Indian ink have confirmed the theory that postangiographic renal damage is due primarily to ischaemia. Cortical ischaemia is due to vascular spasm and sludging caused by contrast medium. Current and previous experimental findings suggest the following course in the pathomechanism: vasospasm reduced blood velocity--aggregation of erythrocytes--further deterioration in the circulation--microemboli--irreversible sludge formation--arterial and venous thromboses--ischaemic foci--necrosis or infarction. It is not possible to prevent this damage by alpha blocking sympathicolytic drugs.
注射印度墨水的实验证实了血管造影术后肾损伤主要是由于缺血这一理论。皮质缺血是由造影剂引起的血管痉挛和血液淤滞所致。当前和以往的实验结果提示了以下病理机制过程：血管痉挛使血流速度减慢——红细胞聚集——循环进一步恶化——微栓子形成——不可逆的血液淤滞形成——动静脉血栓形成——缺血灶——坏死或梗死。使用α受体阻断性抗交感神经药物无法预防这种损伤。
