Howden C W
University of South Carolina, Columbia.
Hepatogastroenterology. 1992 Feb;39 Suppl 1:45-6.
In the consideration of potent versus mild suppression of gastric acid secretion in the treatment of peptic ulcer disease, it must be remembered that pharmacological effect in terms of degree of suppression of acidity is closely linked to therapeutic efficacy in terms of numbers of ulcers healed. More potent degrees of suppression of acidity result in faster ulcer healing. Moderate suppression of acidity, such as is achieved by the H2RA, can heal just as many ulcers if treatment is continued longer. Mild acid suppression will take still longer to produce the same healing rates. Therapeutic benefit of any treatment must be assessed also in terms of the side-effect profile of the drug or drugs used. There is an enormous cumulative experience with the H2RA as a group and they are known to have an excellent safety profile.
在考虑强力抑制胃酸分泌与轻度抑制胃酸分泌在消化性溃疡疾病治疗中的作用时，必须记住，就胃酸抑制程度而言的药理作用与就愈合溃疡数量而言的治疗效果密切相关。更强程度的胃酸抑制会导致溃疡愈合更快。适度抑制胃酸，如使用H2受体拮抗剂所达到的效果，如果持续更长时间治疗，也能愈合同样数量的溃疡。轻度胃酸抑制则需要更长时间才能达到相同的愈合率。任何治疗的治疗益处还必须根据所用药物的副作用情况来评估。作为一个药物类别，H2受体拮抗剂有大量的累积经验，并且已知它们具有出色的安全性。
