Buckland P R, O'Donovan M C, McGuffin P
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Psychopharmacology (Berl). 1992;106(4):479-83. doi: 10.1007/BF02244818.
The effects of administration of antipsychotic drugs (1-32 days, twice per day) on the rat brain mRNA levels of dopamine D1, D2 and D3 receptors has been assessed by a novel procedure utilising solution hybridisation with oligonucleotides. Saline and sulpiride (10 mg/kg/injection) had no effect on D1, D2 and D3 receptor mRNA levels. Haloperidol (1.5 mg/kg/injection) elicited increases in D1, D2 and D3 receptor mRNA levels of 100%, 100% and 300% respectively, after 32 days and loxapine (2 mg/kg/injection) elicited increases of 450%, 150% and 550%, respectively. These results indicate that the up-regulation of dopamine receptors may be associated with the occurrence of tardive dyskinesia but not the clinical mode of action of antipsychotics.
通过一种利用与寡核苷酸进行溶液杂交的新方法，评估了抗精神病药物给药（1 - 32天，每天两次）对大鼠脑内多巴胺D1、D2和D3受体mRNA水平的影响。生理盐水和舒必利（每次注射10 mg/kg）对D1、D2和D3受体mRNA水平无影响。氟哌啶醇（每次注射1.5 mg/kg）在32天后使D1、D2和D3受体mRNA水平分别升高100%、100%和300%，洛沙平（每次注射2 mg/kg）使D1、D2和D3受体mRNA水平分别升高450%、150%和550%。这些结果表明，多巴胺受体的上调可能与迟发性运动障碍的发生有关，但与抗精神病药物的临床作用方式无关。
