Buckland P R, O'Donovan M C, McGuffin P
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Eur Neuropsychopharmacol. 1992 Dec;2(4):405-9. doi: 10.1016/0924-977x(92)90002-p.
The effects of administration of antipsychotic drugs (haloperidol, loxapine, sulpiride; 1-32 day time course) on the rat brain mRNA levels of the dopamine D5 receptor has been assessed using solution hybridisation with oligonucleotides. In contrast with the previously reported increases of D1, D2 and D3 receptor mRNA levels in identical experiments, no changes were found in dopamine D5 receptor mRNA levels, suggesting that the mechanism of regulation of D5 receptor mRNA is different to the other cloned dopamine receptors. We also conclude that up-regulation of the D5 receptor is not likely to be involved in the mechanism of action of antipsychotic drugs.
已通过与寡核苷酸的溶液杂交法评估了抗精神病药物（氟哌啶醇、洛沙平、舒必利；1 - 32天时间进程）给药对大鼠脑内多巴胺D5受体mRNA水平的影响。与之前在相同实验中报道的D1、D2和D3受体mRNA水平升高相反，多巴胺D5受体mRNA水平未发现变化，这表明D5受体mRNA的调节机制与其他克隆的多巴胺受体不同。我们还得出结论，D5受体的上调不太可能参与抗精神病药物的作用机制。
