Wisén O, Björvell H, Cantor P, Johansson C, Theodorsson E
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Regul Pept. 1992 Apr 29;39(1):43-54. doi: 10.1016/0167-0115(92)90007-h.
Plasma concentrations of regulatory peptides were monitored in groups of obese and normal-weight subjects following modified sham feeding and a liquid fatty meal. Following modified sham feeding a significant increase in immunoreactive cholecystokinin (CCK) in plasma was recorded in both groups. In the obese subjects, however, the concentrations following sham feeding were significantly lower than in normal-weight subjects, and the initial part of the response was negative. Basal and modified sham feeding stimulated immunoreactive pancreatic polypeptide (PP) concentrations in plasma did not differ between the groups. After the liquid fatty meal plasma CCK concentrations increased similarly in both groups. In contrast immunoreactive neurotensin and somatostatin concentrations following the meal were lower in the obese group, and a changed concentration-time pattern for somatostatin was observed in the obese group. Postprandial concentrations of PP and immunoreactive gastrin were not different in the groups. The results indicate that the plasma concentration patterns of CCK, somatostatin and NT are disarranged in obesity. The changes may promote rapid propulsion and absorption of ingested food, and facilitate deposition of fat in adipose tissue in obesity and thus may be of pathophysiological importance.
在肥胖和体重正常的受试者组中，在改良假饲和液体脂肪餐后监测调节肽的血浆浓度。在改良假饲后，两组受试者血浆中免疫反应性胆囊收缩素（CCK）均显著增加。然而，肥胖受试者假饲后的浓度显著低于体重正常的受试者，且反应的初始部分为阴性。两组之间基础和改良假饲刺激的血浆中免疫反应性胰多肽（PP）浓度没有差异。液体脂肪餐后两组血浆CCK浓度的增加相似。相比之下，肥胖组餐后免疫反应性神经降压素和生长抑素浓度较低，且在肥胖组中观察到生长抑素浓度-时间模式的改变。餐后两组PP和免疫反应性胃泌素的浓度没有差异。结果表明，肥胖患者中CCK、生长抑素和神经降压素的血浆浓度模式紊乱。这些变化可能促进摄入食物的快速推进和吸收，并有助于肥胖患者脂肪在脂肪组织中的沉积，因此可能具有病理生理学意义。
