N-甲基-D-天冬氨酸（NMDA）、非NMDA和甘氨酸受体介导外侧上橄榄核中的双耳相互作用：来自小鼠脑片的生理学证据。

NMDA, non-NMDA and glycine receptors mediate binaural interaction in the lateral superior olive: physiological evidence from mouse brain slice.

作者信息

Wu S H, Kelly J B

机构信息

Psychology Department, Carleton University, Ottawa, Ont., Canada.

出版信息

Neurosci Lett. 1992 Jan 6;134(2):257-60. doi: 10.1016/0304-3940(92)90529-g.

DOI:10.1016/0304-3940(92)90529-g

PMID:1350335

Abstract

Binaural interaction was investigated in a 400 microns brain slice taken through the mouse lateral superior olive (LSO). Ipsilateral excitatory and contralateral inhibitory inputs to LSO neurons were examined by recording physiological responses to electrical stimulation of the trapezoid body. Bath application of non-N-methyl-D-aspartate (non-NMDA) antagonists blocked ipsilateral excitation and strychnine blocked contralateral inhibition. N-methyl-D-aspartate (NMDA) had little effect on ipsilateral responses but completely blocked contralateral inhibition. These results suggest that ipsilateral excitation is mediated by non-NMDA receptors and contralateral inhibition by strychnine dependent glycine receptors. NMDA receptors may play a role by modulating contralateral inhibition in LSO.

摘要

通过小鼠外侧上橄榄核（LSO）制作的400微米脑片来研究双耳相互作用。通过记录对梯形体电刺激的生理反应，来检测LSO神经元的同侧兴奋性输入和对侧抑制性输入。浴用非N-甲基-D-天冬氨酸（非NMDA）拮抗剂可阻断同侧兴奋，而士的宁可阻断对侧抑制。N-甲基-D-天冬氨酸（NMDA）对同侧反应影响很小，但完全阻断了对侧抑制。这些结果表明，同侧兴奋由非NMDA受体介导，对侧抑制由士的宁依赖性甘氨酸受体介导。NMDA受体可能通过调节LSO中的对侧抑制发挥作用。