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In utero treatment with monoclonal antibody to IL-2 receptor beta-chain completely abrogates development of Thy-1+ dendritic epidermal cells.

作者信息

Tanaka T, Takeuchi Y, Shiohara T, Kitamura F, Nagasaka Y, Hamamura K, Yagita H, Miyasaka M

机构信息

Department of Immunology, Tokyo Metropolitan Institute of Medical Science, Japan.

出版信息

Int Immunol. 1992 Apr;4(4):487-91. doi: 10.1093/intimm/4.4.487.

DOI:10.1093/intimm/4.4.487
PMID:1350462
Abstract

Interleukin-2 (IL-2), a crucial growth factor for mature T lymphocytes, is produced in fetal thymus under developmental control, although its biological significance remains unclear. We found that the two distinct subunits of the IL-2 receptor, i.e. the alpha-chain (IL-2R alpha) and the beta-chain (IL-2R beta), were expressed in an almost mutually exclusive fashion throughout fetal thymus ontogeny, and that the blockade of IL-2R beta, a signal transducing component of IL-2R, by administering a neutralizing mAb to IL-2R beta resulted in the complete and selective disappearance of Thy-1+ skin dendritic epidermal cells. Development of any other T cell subsets was uncompromised. This indicates that IL-2 plays a crucial role in the development of fetal V gamma 5+ cells and their descendants.

摘要

相似文献

1
In utero treatment with monoclonal antibody to IL-2 receptor beta-chain completely abrogates development of Thy-1+ dendritic epidermal cells.
Int Immunol. 1992 Apr;4(4):487-91. doi: 10.1093/intimm/4.4.487.
2
Dysregulated expression of the IL-2 receptor beta-chain abrogates development of NK cells and Thy-1+ dendritic epidermal cells in transgenic mice.白细胞介素-2受体β链的表达失调会阻碍转基因小鼠中自然杀伤细胞和Thy-1⁺树突状表皮细胞的发育。
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3
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5
Identification and cellular distribution of the rat interleukin-2 receptor beta chain: induction of the IL-2R alpha- beta+ phenotype by major histocompatibility complex class I recognition during T cell development in vivo and by T cell receptor stimulation of CD4+8+ immature thymocytes in vitro.大鼠白细胞介素-2受体β链的鉴定及其细胞分布：体内T细胞发育过程中主要组织相容性复合体I类识别以及体外T细胞受体刺激CD4+8+未成熟胸腺细胞诱导IL-2Rα-β+表型。
Eur J Immunol. 1996 Oct;26(10):2371-5. doi: 10.1002/eji.1830261015.
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Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice.通过抗白细胞介素2受体β链单克隆抗体在小鼠体内选择性长期清除自然杀伤细胞。
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Expression and role of interleukin-2 receptor beta chain on CD4-CD8- T cell receptor alpha beta+ cells [corrected].白细胞介素-2受体β链在CD4-CD8-T细胞受体αβ+细胞上的表达及作用[校正后]
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10
Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells.αIEL β7整合素在T细胞受体γδ和T细胞受体αβ T细胞上的发育表达。
Eur J Immunol. 1994 Mar;24(3):635-40. doi: 10.1002/eji.1830240322.

引用本文的文献

1
The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites.即刻早期基因产物Egr-1通过非典型的Egr和Sp1结合位点调控人白细胞介素-2受体β链启动子。
Mol Cell Biol. 1997 Jul;17(7):3714-22. doi: 10.1128/MCB.17.7.3714.
2
Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain.缺乏白细胞介素-2受体β链的小鼠肠道上皮内淋巴细胞和外周自然杀伤细胞的异常发育。
J Exp Med. 1997 Feb 3;185(3):499-505. doi: 10.1084/jem.185.3.499.
3
Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.
白细胞介素-15和白细胞介素-2对双潜能T/自然杀伤祖细胞分化的不同作用。
J Exp Med. 1996 Aug 1;184(2):325-36. doi: 10.1084/jem.184.2.325.
4
Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice.通过抗白细胞介素2受体β链单克隆抗体在小鼠体内选择性长期清除自然杀伤细胞。
J Exp Med. 1993 Sep 1;178(3):1103-7. doi: 10.1084/jem.178.3.1103.
5
The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.白细胞介素（IL）-2受体β链为IL-2和一种细胞因子（暂命名为IL-T）所共有，IL-T可刺激T细胞增殖并诱导淋巴因子激活的杀伤细胞。
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4940-4. doi: 10.1073/pnas.91.11.4940.
6
Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice.在p56lck蛋白酪氨酸激酶缺陷型和CD45蛋白酪氨酸磷酸酶缺陷型小鼠中，Vγ3树突状表皮T细胞发育受损。
J Exp Med. 1995 Jan 1;181(1):345-9. doi: 10.1084/jem.181.1.345.
7
Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7.通过针对白细胞介素2、4和7受体的γc亚基的抗体阻断T淋巴细胞和B淋巴细胞的发育。
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5689-93. doi: 10.1073/pnas.92.12.5689.