Bowes M P, Peters R H, Kernan W J, Hopper D L
Department of Neurosciences, University of California, San Diego, La Jolla 92093-0624.
Pharmacol Biochem Behav. 1992 Apr;41(4):707-13. doi: 10.1016/0091-3057(92)90216-3.
Yohimbine, an alpha 2 adrenergic antagonist, facilitates copulatory behaviors in male rats. This facilitation may reflect nonspecific activation of behavior rather than a more selective activation of copulatory behaviors. The present experiments assessed the effects of yohimbine on locomotor behaviors at a dose (2.0 mg/kg) known to facilitate sexual behaviors. Experiment 1 used a computer pattern-recognition system to classify motor behaviors into specific acts and act groups. Male albino rats were tested in three conspecific conditions: estrous female, anestrous female, or no conspecific. Yohimbine decreased locomotor activity in all three conspecific conditions. Experiment 2 examined the effects of yohimbine (2.0 mg/kg) and amphetamine (1.0 mg/kg) on locomotor behavior in a photocell-equipped activity measurement system. Amphetamine increased and yohimbine decreased locomotor activity. Experiment 3 used the computer pattern-recognition system to compare the effects of yohimbine and idazoxan, another alpha 2 adrenergic antagonist, on motor behaviors. Yohimbine and idazoxan both decreased activity but produced different patterns of behavioral change. The facilitatory effects of yohimbine on copulatory behaviors at a dose of 2.0 mg/kg are apparently not mediated by nonspecific activation of behavior.
育亨宾是一种α2肾上腺素能拮抗剂，可促进雄性大鼠的交配行为。这种促进作用可能反映了行为的非特异性激活，而非对交配行为更具选择性的激活。本实验评估了已知能促进性行为的剂量（2.0毫克/千克）的育亨宾对运动行为的影响。实验1使用计算机模式识别系统将运动行为分类为特定动作和动作组。雄性白化大鼠在三种同种条件下进行测试：发情期雌性、乏情期雌性或无同种个体。在所有三种同种条件下，育亨宾均降低了运动活性。实验2在配备光电管的活动测量系统中研究了育亨宾（2.0毫克/千克）和苯丙胺（1.0毫克/千克）对运动行为的影响。苯丙胺增加了运动活性，而育亨宾降低了运动活性。实验3使用计算机模式识别系统比较了育亨宾和另一种α2肾上腺素能拮抗剂伊达唑烷对运动行为的影响。育亨宾和伊达唑烷均降低了活性，但产生了不同的行为变化模式。2.0毫克/千克剂量的育亨宾对交配行为的促进作用显然不是由行为的非特异性激活介导的。
