紫杉醇对巨噬细胞功能的影响。与一些免疫学参数的相互作用。
Effects of taxol on the macrophage function. Interactions with some immunological parameters.
作者信息
Bottex-Gauthier C, Condemine F, Picot F, Vidal D
机构信息
Research Centre, Army Health Service, La Tronche, France.
出版信息
Immunopharmacol Immunotoxicol. 1992;14(1-2):39-61. doi: 10.3109/08923979209009212.
The effects of Taxol on some immunological parameters were investigated, in vitro, in the murine macrophage cell line J774.1. Mitochondrial dehydrogenase activity and (3H) TdR incorporation were shown to be increased in Taxol treated cells. Likewise, Taxol induced TNF alpha secretion. But Taxol seemed to be a weak inducer of the two interleukins IL-1 and IL-2, since their detection occurred late in the cell culture supernatants.
在体外对小鼠巨噬细胞系J774.1研究了紫杉醇对一些免疫学参数的影响。结果显示，经紫杉醇处理的细胞中线粒体脱氢酶活性和（3H）胸腺嘧啶核苷掺入增加。同样，紫杉醇可诱导肿瘤坏死因子α分泌。但紫杉醇似乎是白细胞介素-1和白细胞介素-2的弱诱导剂，因为在细胞培养上清液中较晚才检测到它们。
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