Wörz R, Reinhardt-Benmalek B, Föh M, Grotemeyer K H, Scharafinski H W
Schmerzzentrum Bad Schönborn.
Fortschr Med. 1992 May 20;110(14):268-72.
Comparison of bisoprolol, a beta-1 selective beta blocker with no intrinsic sympathomimetic activity (ISA) and metoprolol, which numerous studies have shown to be an effective migraine prophylactic.
Multicentric, cross-over study.
125 patients suffering at least from 3 attacks of classic or common migraine a month for at least two years.
Bisoprolol 5 mg given once a day, or metoprolol 50 mg given twice a day, for two periods of 12 weeks.
125 patients were admitted to the 4-week run-in phase. A comparison of the main target: frequency of migraine attacks was thus carried out in 78 patients (f. = 63, m. = 15). Both substances reduced the average frequency of migraine per 28-day period by about 50%. There was no statistically significant difference between the two beta-blockers (p greater than 0.05).
The results of the study show that 5 mg of bisoprolol and 100 mg of metoprolol a day have comparable efficacy for migraine prophylaxis, and show comparable tolerability.
比较比索洛尔（一种无内在拟交感活性（ISA）的β1选择性β受体阻滞剂）和美托洛尔（众多研究已表明其为一种有效的偏头痛预防性药物）。
多中心交叉研究。
125例每月至少发作3次典型或普通偏头痛且持续至少两年的患者。
比索洛尔5毫克每日一次，或美托洛尔50毫克每日两次，各治疗12周。
125例患者进入4周导入期。因此在78例患者（女 = 63，男 = 15）中对主要指标：偏头痛发作频率进行了比较。两种药物均使每28天的偏头痛平均发作频率降低约50%。两种β受体阻滞剂之间无统计学显著差异（p＞0.05）。
研究结果表明，每日5毫克比索洛尔和100毫克美托洛尔在偏头痛预防方面具有相当的疗效，且耐受性相当。
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