Jaatinen P, Kiianmaa K, Hervonen A
Department of Public Health, University of Tampere, Finland.
Mech Ageing Dev. 1992 Apr;63(2):193-205. doi: 10.1016/0047-6374(92)90065-l.
The effects of aging and chronic ethanol administration on the histochemical and morphometric features of rat superior cervical ganglion were studied in a rat strain selected for voluntary alcohol consumption. Ethanol was administered to the experimental group ad libitum (10% v/v in drinking water) from 3 months to 28 months of age, the average ethanol intake being 6.4-5.4 g/kg per day. The sympathetic neurons of the ethanol consuming rats showed several signs of enhanced degeneration, e.g. decreased neuronal packing density, increased amount of age-pigment and decreased intensity of catecholamine histofluorescence and tyrosine hydroxylase immunoreactivity. The results may indicate a selective vulnerability of peripheral sympathetic neurons rather than a universal accelerated aging due to chronic ethanol exposure.
在一个因自愿饮酒而被挑选出的大鼠品系中，研究了衰老和长期给予乙醇对大鼠颈上神经节组织化学和形态计量学特征的影响。从3月龄至28月龄，给实验组大鼠随意饮用乙醇（饮用水中体积分数为10%），乙醇平均摄入量为每天6.4 - 5.4 g/kg。饮用乙醇的大鼠交感神经元显示出几种变性增强的迹象，例如神经元堆积密度降低、老年色素量增加、儿茶酚胺组织荧光强度降低以及酪氨酸羟化酶免疫反应性降低。结果可能表明外周交感神经元具有选择性易损性，而非因长期接触乙醇导致普遍的加速衰老。
