Fonnum F, Malthe-Sørenssen D, Lund-Karlsen R, Oddan E
Norwegian Defense Research Establishment, Division for Environmental Toxicology, Kjeller.
Brain Res. 1992 May 1;579(1):74-8. doi: 10.1016/0006-8993(92)90743-s.
A single subcutaneous injection of L-cysteine (1.2 mg/g body wt.) to 4-day-old rats leads to atrophy of the brains examined 27-31 days later. The brains could be separated into two groups (type 1 and 2) on account of the degree of atrophy. Type-1 lesion, with a brain weight reduction of 20%, was dominated by a severe reduction in high-affinity uptake of L-glutamate in CNS regions receiving corticofugal fibers such as thalamus and striatum. Glutamate decarboxylase was only reduced in cortical structures. In type-2 lesion, with a severe brain atrophy of about 50%, high-affinity glutamate uptake was further reduced and there was a more pronounced reduction in glutamate decarboxylase activity in several brain regions. Cholinergic neurons were less affected by the lesion and the levels of choline acetyltransferase showed a relative increase in brain regions which partly compensated for their reduction in size.
对4日龄大鼠单次皮下注射L-半胱氨酸（1.2毫克/克体重），会导致27至31天后所检查的大脑出现萎缩。根据萎缩程度，大脑可分为两组（1型和2型）。1型损伤中，脑重减轻20%，主要表现为在接受皮质传出纤维的中枢神经系统区域（如丘脑和纹状体）中，L-谷氨酸的高亲和力摄取严重减少。谷氨酸脱羧酶仅在皮质结构中减少。在2型损伤中，大脑严重萎缩约50%，高亲和力谷氨酸摄取进一步减少，且几个脑区的谷氨酸脱羧酶活性有更明显的降低。胆碱能神经元受损伤的影响较小，胆碱乙酰转移酶水平在脑区呈现相对升高，部分补偿了其体积的减小。
