Stoff D M, Wyatt R J, Gillin J C
Psychopharmacology (Berl). 1976 Jun 23;47(3):287-92. doi: 10.1007/BF00427615.
Acute parachlorophenylalanine (pCPA) pretreatment (150 mg/kg, i.p., 24 h beforehand) potentiated facilitatory effects of mescaline (39.6 mg/kg i.p.) on shuttlebox escape/avoidance in hooded rats, tested in two different situations: 1. during aquisition of avoidance behavior (Experiment 1); and 2. in stable pretrained poor avoiders (Experiment 2). pCPA alone did not influence avoidance behavior in either situation. Mescaline, with pCPA pretreatment, may be associated with long-term behavioral effects; all rats treated with this combination were later found to be poor avoiders, unable to achieve a stable baseline of good avoidance. pCPA significantly depleted brain norepinephrine and dopamine, as well as serotonin, measured after testing in the second situation.
急性对氯苯丙氨酸（pCPA）预处理（150毫克/千克，腹腔注射，提前24小时）增强了三甲氧苯乙胺（39.6毫克/千克，腹腔注射）对有头罩大鼠穿梭箱逃避/回避行为的促进作用，在两种不同情况下进行测试：1. 在回避行为习得期间（实验1）；2. 在稳定的预训练差回避者中（实验2）。单独使用pCPA在两种情况下均不影响回避行为。经pCPA预处理的三甲氧苯乙胺可能与长期行为效应有关；后来发现所有接受这种组合治疗的大鼠都是差回避者，无法达到稳定的良好回避基线。在第二种情况下测试后测量发现，pCPA显著消耗了大脑中的去甲肾上腺素、多巴胺以及血清素。
