Nygaard H A, Fuglum E, Elgen K
Fyllingsdalen Sykehjem, Norway.
Curr Med Res Opin. 1992;12(10):615-22. doi: 10.1185/03007999209111528.
A meta-analysis was carried out of the data from two double-blind, multi-centre studies with identical methodology which compared the effectiveness of treatment of elderly patients with zuclopenthixol and with other antipsychotic drugs. In one study, patients were treated for 4 weeks with either zuclopenthixol or melperone; in the other, with either zuclopenthixol or a combination of haloperidol and levomepromazine. The meta-analysis evaluated the results of 96 patients, 49 in the zuclopenthixol group and 47 in the comparison group. Doses, which were adjusted to individual patient's needs, were low as shown by the percentages of defined daily doses for each of the study drugs. The results indicated that all three treatment alternatives were effective in the treatment of elderly patients with symptoms of agitation and hostility/aggressiveness. There was a trend, however, for zuclopenthixol to have a more rapid onset of effect. Zuclopenthixol also has the advantage for both patients and nursing staff that dosage is once daily. Only few and mild side-effects were reported with the three drug regimens.
对两项采用相同方法的双盲、多中心研究的数据进行了荟萃分析，这两项研究比较了珠氯噻醇与其他抗精神病药物治疗老年患者的疗效。在一项研究中，患者用珠氯噻醇或美哌隆治疗4周；在另一项研究中，患者用珠氯噻醇或氟哌啶醇与左美丙嗪的组合治疗。荟萃分析评估了96例患者的结果，其中珠氯噻醇组49例，对照组47例。根据每位患者的需求调整剂量，各研究药物的限定日剂量百分比显示剂量较低。结果表明，所有三种治疗方案对有激越和敌意/攻击性症状的老年患者均有效。然而，有迹象表明珠氯噻醇起效更快。珠氯噻醇对患者和护理人员还有一个优势，即每日给药一次。三种药物治疗方案报告的副作用均较少且轻微。
