Nand N, Sharma M, Saini D S, Khosla S N
Department of Medicine IV and Biochemistry, Medical College and Hospital, Rohtak.
J Assoc Physicians India. 1992 Mar;40(3):167-9.
Gamma glutamyl transpeptidase (GGTP) was measured serially in cerebrospinal fluid (CSF) and serum in 23 cases of meningitis (15 pyogenic and 8 tuberculous meningitis) and an equal number of age and sex matched healthy controls, to find out its diagnostic and prognostic significance in meningitis. GGTP activity was significantly elevated (p less than 0.001) in CSF and serum in meningitis as compared to control subjects. Levels were significantly higher in pyogenic as compared to tuberculous meningitis (p less than 0.001) and in CSF than in serum (p less than 0.001). The maximum elevation was seen on the 1st day and thereafter the activity declined in the majority (65.2%) of cases. However, in 3 cases of pyogenic meningitis and 5 cases of tuberculous meningitis, the GGTP activity on subsequent estimation increased serially; all these 8 cases died. It is concluded that CSF GGTP activity is significantly elevated in meningitis and serial rise in its activity is associated with poor prognosis and even fatal outcome.
对23例脑膜炎患者（15例化脓性脑膜炎和8例结核性脑膜炎）以及年龄和性别相匹配的同等数量健康对照者的脑脊液（CSF）和血清中的γ-谷氨酰转肽酶（GGTP）进行了连续检测，以明确其在脑膜炎中的诊断和预后意义。与对照受试者相比，脑膜炎患者脑脊液和血清中的GGTP活性显著升高（p<0.001）。化脓性脑膜炎患者的水平显著高于结核性脑膜炎患者（p<0.001），脑脊液中的水平高于血清（p<0.001）。大多数（65.2%）病例在第1天出现最大升高，此后活性下降。然而，3例化脓性脑膜炎患者和5例结核性脑膜炎患者随后检测的GGTP活性持续升高；这8例患者均死亡。结论是，脑膜炎患者脑脊液中的GGTP活性显著升高，其活性持续升高与预后不良甚至致命结局相关。
