Chen C C, Fujiwara Y, Akiyama K, Ujike H, Moriya F, Otsuki S
Department of Neuropsychiatry, Okayama University Medical School, Japan.
Jpn J Psychiatry Neurol. 1992 Mar;46(1):197-203. doi: 10.1111/j.1440-1819.1992.tb00834.x.
Emerging evidences have suggested that the brain serotonin (5-hydroxytryptamine, 5-HT) neurotransmitter system is involved in the compulsive alcohol-seeking behaviors in humans and animal models. The aim of this study is to examine the effect of ipsapirone, which is a specific 5-HT1A agonist with a pyrimidinylpiperazine structure, on alcohol consumption in mice (C57BL/6J) by a voluntary alcohol intake paradigm. When the consumed alcohol was expressed as g/kg B.W., the total 12-day amount was significantly lower in the ipsapirone-treated mice than in the saline-treated mice. However, 5-HT1A receptor binding sites labeled with [3H]8-OH-DPAT in hippocampal membranes did not differ significantly in either the total number of binding sites (Bmax) or dissociation constant (Kd) between the two groups. The possible mechanism regarding the role of ipsapirone that attenuated the alcohol consumption, and its relationship to the subtyping 5-HT receptors are further discussed.
新出现的证据表明，大脑血清素（5-羟色胺，5-HT）神经递质系统参与人类和动物模型中强迫性觅酒行为。本研究的目的是通过自愿酒精摄入范式，研究具有嘧啶基哌嗪结构的特异性5-HT1A激动剂伊沙匹隆对小鼠（C57BL/6J）酒精摄入量的影响。当以克/千克体重表示摄入的酒精量时，伊沙匹隆处理组小鼠12天的总量显著低于生理盐水处理组小鼠。然而，两组海马膜中用[3H]8-OH-DPAT标记的5-HT1A受体结合位点在结合位点总数（Bmax）或解离常数（Kd）方面均无显著差异。进一步讨论了伊沙匹隆减少酒精摄入作用的可能机制及其与5-HT受体亚型的关系。
