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[骨科与创伤科中的血栓栓塞并发症。对598例手术患者的前瞻性研究]

[Thromboembolism complications in orthopedics and traumatology. A prospective study of 598 operated patients].

作者信息

Krüger-Franke M, Hagena F W, Weber W

机构信息

Staatliche Orthopädische Klinik München.

出版信息

Aktuelle Traumatol. 1992 Jun;22(3):114-9.

PMID:1353290
Abstract

From 1.10.-31.12. 1989, 598 patients who underwent orthopaedic surgery in the Staatliche Orthopädische Klinik were examined by a pre-, intra- and postoperative questionnaire up to 3 months from the date of operation. All patients were separated into 4 groups corresponding to the calculated risk and duration of the operation. 46 patients in Group I, who underwent minor surgery, received 3 x 5000 I.E. Heparin subcutaneously. 243 patients in Group II received besides 3 x 5000 I.E. Heparin, 500 ml HAES 6% preoperatively. They underwent operations of greater intensity and duration at the upper and lower extremities. 302 patients of Group III were given 3 x 5000 I.E. heparin and 500 ml 6% dextrane 60 preoperatively because of severe operations (pelvis, hip). 7 high-risk patients received apart from 3 x 5000 I.E. Heparin subcutaneously 500 ml 6% dextrane 60 preoperatively and 250ml 10% dextrane 40 postoperatively for 5 days. In Group I we had 2.2% thromboembolic complications, whereas in Group II 1.7% and in Group III 3.3% complications with thrombosis and pulmonary embolism occurred. This was proved by pulmonary scintigraphy and phlebography. No such complications were seen in Group IV. The total incidence of deep vein thrombosis was 2.0% and of pulmonary embolism 0.5%. These results show the importance of preoperative risk check and individual prophylaxis of thromboembolic complications in orthopaedic and traumatologic surgery.

摘要

1989年10月1日至12月31日,对在国家骨科诊所接受骨科手术的598例患者,于术前、术中和术后直至手术日期后3个月进行问卷调查。所有患者根据计算出的风险和手术时长分为4组。第一组46例接受小手术的患者,皮下注射3次,每次5000国际单位肝素。第二组243例患者,除皮下注射3次,每次5000国际单位肝素外,术前还输注500毫升6%贺斯。他们接受了上下肢强度和时长更大的手术。第三组302例患者因进行大手术(骨盆、髋关节),术前给予3次,每次5000国际单位肝素和500毫升6%右旋糖酐60。7例高危患者除皮下注射3次,每次5000国际单位肝素外,术前还输注500毫升6%右旋糖酐60,术后5天输注250毫升10%右旋糖酐40。第一组血栓栓塞并发症发生率为2.2%,而第二组为1.7%,第三组血栓形成和肺栓塞并发症发生率为3.3%。这通过肺闪烁造影和静脉造影得以证实。第四组未见此类并发症。深静脉血栓形成的总发生率为2.0%,肺栓塞为0.5%。这些结果表明术前风险检查以及骨科和创伤外科中血栓栓塞并发症个体化预防的重要性。

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