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Subcellular compartmentation of 2'methyl MPP+ can explain differences in toxicity to adrenal chromaffin cells.

作者信息

Reinhard J F, Daniels A J

机构信息

Division of Pharmacology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709.

出版信息

Ann N Y Acad Sci. 1992 May 11;648:323-5. doi: 10.1111/j.1749-6632.1992.tb24569.x.

DOI:10.1111/j.1749-6632.1992.tb24569.x
PMID:1353333
Abstract
摘要

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Subcellular compartmentation of 2'methyl MPP+ can explain differences in toxicity to adrenal chromaffin cells.2'-甲基MPP+的亚细胞区室化可以解释其对肾上腺嗜铬细胞毒性的差异。
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Carrier-independent entry of 1-methyl-4-phenylpyridinium (MPP+) into adrenal chromaffin cells as a consequence of charge delocalization.由于电荷离域,1-甲基-4-苯基吡啶离子(MPP+)不依赖载体进入肾上腺嗜铬细胞。
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