Sherry-McKenna R L, Baker G B, Mousseau D D, Coutts R T, Dewhurst W G
Department of Psychiatry, Mackenzie Centre, University of Alberta, Edmonton, Canada.
Biol Psychiatry. 1992 May 1;31(9):881-8.
4-Methoxytranylcypromine (MeOTCP), a ring-substituted analogue of the monoamine oxidase (MAO)-inhibiting antidepressant tranylcypromine (TCP), was investigated in the rat after chronic (28-day) administration and the results compared with those observed with TCP using equimolar doses of both drugs. At the dose tested, MeOTCP produced a greater inhibition of type A MAO in brain, liver, and heart than did TCP. Both drugs caused a reduction in the specific binding to beta-adrenergic and tryptamine receptors in cortex from brain. MeOTCP produced a marked increase in 5-hydroxytryptamine levels in pons-medulla, hypothalamus, and hippocampus relative to values in vehicle-treated rats and also produced a significant increase in these levels over those observed in the TCP-treated rats.
4-甲氧基反苯环丙胺（MeOTCP）是单胺氧化酶（MAO）抑制性抗抑郁药反苯环丙胺（TCP）的一种环取代类似物，在大鼠中进行了慢性（28天）给药研究，并将结果与使用等摩尔剂量的两种药物观察到的TCP结果进行了比较。在所测试的剂量下，MeOTCP对大脑、肝脏和心脏中A型MAO的抑制作用比TCP更强。两种药物都导致大脑皮层中β-肾上腺素能和色胺受体的特异性结合减少。相对于用赋形剂处理的大鼠，MeOTCP使脑桥-延髓、下丘脑和海马体中的5-羟色胺水平显著升高，并且这些水平相对于TCP处理的大鼠也有显著增加。
