A new chromosomal breakpoint in Ph positive, bcr negative chronic myelogenous leukemia. Report of a case.
作者信息
Negrini M, Tallarico A, Pazzi I, Castagnoli A, Cuneo A, Castoldi G L
机构信息
Interdepartment Center for Cancer Research, University of Ferrara, Italy.
出版信息
Cancer Genet Cytogenet. 1992 Jul 1;61(1):11-3. doi: 10.1016/0165-4608(92)90363-d.
PMID:1353407
Abstract
We report a new case of Ph positive chronic myeloid leukemia (CML) without the classical rearrangement in Mbcr. By Southern blot analysis the molecular breakpoint was mapped 3 to 8 kb upstream of Mbcr. This region has not been shown to be rearranged in any other described case of CML. We did not detect any specific abnormal BCR-ABL transcript even with the use of the very sensitive RNA-PCR technique.
摘要
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