尼可地尔、匹那地尔和雷马卡林对犬脑动脉的血管舒张作用。

Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.

Zhang H, Stockbridge N, Weir B, Vollrath B, Cook D

Department of Surgery, University of Alberta, Edmonton, Canada.

Gen Pharmacol. 1992 Mar;23(2):197-201. doi: 10.1016/0306-3623(92)90009-9.

Abstract

Nicorandil, pinacidil and lemakalim relaxed precontracted rings of canine cerebral artery. 2. The order of potency was lemakalim greater than nicorandil approximately equal to pinacidil, but all these agents were less effective than nimodipine. 3. The effects of nicorandil were inhibited by methylene blue but not by glibenclamide, while the effects of pinacidil and lemakalim were inhibited by glibenclamide but not by methylene blue. 4. Thus nicorandil probably causes relaxation mostly by effects on guanylate cyclase while lemakalim and pinacidil produce the same effect by action at ATP-dependent potassium channels.

摘要

尼可地尔、匹那地尔和雷马卡林可使预先收缩的犬脑动脉环舒张。2. 效价顺序为雷马卡林大于尼可地尔，尼可地尔约等于匹那地尔，但所有这些药物的效果均不如尼莫地平。3. 尼可地尔的作用被亚甲蓝抑制，但不被格列本脲抑制，而匹那地尔和雷马卡林的作用被格列本脲抑制，但不被亚甲蓝抑制。4. 因此，尼可地尔可能主要通过对鸟苷酸环化酶的作用引起舒张，而雷马卡林和匹那地尔则通过作用于ATP依赖性钾通道产生相同的效果。