Díaz-Miranda L, de Motta G E, García-Arrarás J E
Department of Biology, University of Puerto Rico, Río Piedras 00931.
J Exp Zool. 1992 Aug 1;263(1):54-67. doi: 10.1002/jez.1402630107.
Pharmacological studies on the body wall musculature of the sedentary polychaete Sabellastarte magnifica show a potential neurotransmitter role for monoamines and neuropeptides in this organism. All catecholamines induced contraction of longitudinal muscle strips, while serotonin and the neuropeptides FMRFamide and substance P caused a relaxation of both resting and active muscle. In addition, we demonstrate catecholaminergic and serotonergic pathways in the nervous system of this sabellid, using immunohistochemistry and catecholamine-induced fluorescence. The presence of neuropeptide-containing fibers in the nervous system of this polychaete has been previously reported. Together these results suggest that catecholamines act as excitatory transmitters on the longitudinal muscle cells of the body wall of S. magnifica, while serotonin and FMRFamide, and possible substance P, are inhibitory transmitters. The possibility of coexistence of serotonin and FMRFamide within the same neuronal cell bodies and fibers of this polychaete is also explored.
对固着多毛纲动物壮丽缨鳃虫体壁肌肉组织的药理学研究表明，单胺类和神经肽在该生物体中具有潜在的神经递质作用。所有儿茶酚胺都会引起纵肌条收缩，而血清素、神经肽FMRF酰胺和P物质则会使静息和活动的肌肉松弛。此外，我们利用免疫组织化学和儿茶酚胺诱导荧光技术，证明了这种缨鳃虫神经系统中存在儿茶酚胺能和血清素能通路。此前已有报道称这种多毛纲动物的神经系统中存在含神经肽的纤维。这些结果共同表明，儿茶酚胺作为兴奋性递质作用于壮丽缨鳃虫体壁的纵肌细胞，而血清素、FMRF酰胺以及可能的P物质则是抑制性递质。同时还探讨了血清素和FMRF酰胺在这种多毛纲动物的同一神经元细胞体和纤维中共存的可能性。
