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实验性同种免疫性肾上腺炎

Experimental iso-immune adrenalitis.

作者信息

COLOVER J, GLYNN L E

出版信息

Immunology. 1958 Apr;1(2):172-8.

PMID:13538533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423895/
Abstract

Lesions of the adrenal glands have been produced in guinea pigs by the intramuscular injection of homologous adrenal gland with a fraction made from heat-killed human tubercle bacilli incorporated in a water-in-oil emulsion. Both the cortex and medulla were affected. Destruction and infiltration of the glandular tissues were observed histologically. Control groups of animals, in some of which the same bacillary fraction and similar adrenal gland suspensions had been injected separately, failed to show the adrenal lesions. This experimental adrenalitis has been compared and contrasted with experimental allergic encephalomyelitis: it is believed both are caused by a similar process, immunological in nature.

摘要

通过肌内注射同源肾上腺组织与掺入油包水乳剂中的热灭活人结核杆菌制成的组分,在豚鼠身上产生了肾上腺病变。皮质和髓质均受到影响。组织学观察到腺组织的破坏和浸润。在一些对照组动物中,分别注射了相同的杆菌组分和类似的肾上腺悬液,但未出现肾上腺病变。已将这种实验性肾上腺炎与实验性过敏性脑脊髓炎进行了比较和对比:据信两者都是由类似的过程引起的,本质上是免疫性的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/331962227c7b/immunology00469-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/24998c8199d8/immunology00469-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/b06a3527d89c/immunology00469-0086-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/ddc37110e201/immunology00469-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/f3aaee7f92c3/immunology00469-0088-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/1ef8a9033acf/immunology00469-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/331962227c7b/immunology00469-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/24998c8199d8/immunology00469-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/b06a3527d89c/immunology00469-0086-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/ddc37110e201/immunology00469-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/f3aaee7f92c3/immunology00469-0088-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/1ef8a9033acf/immunology00469-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77ca/1423895/331962227c7b/immunology00469-0089-b.jpg

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本文引用的文献

1
Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts.器官特异性研究。V. 用兔甲状腺提取物进行主动免疫后家兔甲状腺的变化。
J Immunol. 1956 Jun;76(6):417-27.
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实验性免疫性肾上腺损伤:佐剂中自体和同源肾上腺抗原注射的反应。
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STUDIES OF THE ADRENAL ANTIGENS AND ANTIBODIES IN ADDISON'S DISEASE.艾迪生病中肾上腺抗原与抗体的研究。
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INDUCTION OF AUTOIMMUNITY TO ADRENAL GLAND.肾上腺自身免疫的诱导。
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Immunological studies on adrenal glands. II. Immunization with adrenals of the same species.肾上腺的免疫学研究。II. 用同种动物的肾上腺进行免疫
Immunology. 1962 Jan;5(1):67-78.
9
Immunological reactions in gastrointestinal disease: a review.胃肠道疾病中的免疫反应:综述
Gut. 1962 Dec;3(4):277-88. doi: 10.1136/gut.3.4.277.
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Transfer of an autoimmune nephrosis in the rat by means of lymph node cells.通过淋巴结细胞转移大鼠自身免疫性肾病
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