COLOVER J, GLYNN L E
Immunology. 1958 Apr;1(2):172-8.
Lesions of the adrenal glands have been produced in guinea pigs by the intramuscular injection of homologous adrenal gland with a fraction made from heat-killed human tubercle bacilli incorporated in a water-in-oil emulsion. Both the cortex and medulla were affected. Destruction and infiltration of the glandular tissues were observed histologically. Control groups of animals, in some of which the same bacillary fraction and similar adrenal gland suspensions had been injected separately, failed to show the adrenal lesions. This experimental adrenalitis has been compared and contrasted with experimental allergic encephalomyelitis: it is believed both are caused by a similar process, immunological in nature.
通过肌内注射同源肾上腺组织与掺入油包水乳剂中的热灭活人结核杆菌制成的组分,在豚鼠身上产生了肾上腺病变。皮质和髓质均受到影响。组织学观察到腺组织的破坏和浸润。在一些对照组动物中,分别注射了相同的杆菌组分和类似的肾上腺悬液,但未出现肾上腺病变。已将这种实验性肾上腺炎与实验性过敏性脑脊髓炎进行了比较和对比:据信两者都是由类似的过程引起的,本质上是免疫性的。