Tjälve H, Wilander E
Acta Endocrinol (Copenh). 1976 Oct;83(2):357-64. doi: 10.1530/acta.0.0830357.
The uptake of the nicotinamide adenine dinucleotide (NAD)-precursors nicotinamide, nicotinic acid and tryptophan in the pancreatic islets of mice was studied by use of autoradiographic methods. The ability of these substances to prevent streptoxotocin diabetes was studied in the same species. It was found that only nicotinamide was strongly accumulated in the pancreatic islets and nicotinamide was also the only NAD-precursor which protected against the streptoxotocin diabetes. Apparently there is a relationship between the ability of the NAD-precursors to be taken up in the pancreatic islets and their ability to prevent streptoxotocin diabetes.
利用放射自显影方法研究了烟酰胺腺嘌呤二核苷酸（NAD）前体烟酰胺、烟酸和色氨酸在小鼠胰岛中的摄取情况。在同一物种中研究了这些物质预防链脲佐菌素糖尿病的能力。结果发现，只有烟酰胺在胰岛中大量蓄积，而且烟酰胺也是唯一能预防链脲佐菌素糖尿病的NAD前体。显然，NAD前体在胰岛中的摄取能力与其预防链脲佐菌素糖尿病的能力之间存在关联。
