Hung D Z, Tsai W J, Deng J F
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Hum Exp Toxicol. 1992 Jul;11(4):289-90. doi: 10.1177/096032719201100410.
Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam. Flumazenil is a benzodiazepine antagonist that is highly effective in reversing the central nervous system effects of benzodiazepine overdose. We report a case of triazolam overdose resulting in anterograde amnesia after flumazenil administration had restored clear consciousness. The defect in memory may have been due to too little flumazenil being given or failure of memory consolidation affected by the character of triazolam during the induced lucent period. We feel that physicians should be aware of the potential occurrence of acute brain syndrome in patients with benzodiazepine overdose despite treatment with flumazenil.
顺行性遗忘，可能伴有急性脑综合征，是某些苯二氮䓬类药物（尤其是三唑仑）的潜在副作用。氟马西尼是一种苯二氮䓬类拮抗剂，在逆转苯二氮䓬类药物过量引起的中枢神经系统效应方面非常有效。我们报告一例三唑仑过量病例，在氟马西尼恢复清醒意识后出现顺行性遗忘。记忆缺陷可能是由于给予的氟马西尼过少，或者在诱导的清醒期受三唑仑特性影响的记忆巩固失败所致。我们认为，尽管使用了氟马西尼进行治疗，医生仍应意识到苯二氮䓬类药物过量患者可能发生急性脑综合征。
