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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Teramoto S, Fukuchi Y, Uejima Y, Ito H, Orimo H

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.

Comp Biochem Physiol Comp Physiol. 1992 Aug;102(4):693-6.

Age-related changes in glutathione (GSH) content of eye lenses were investigated in senescence-accelerated mouse (SAM) and C57BL/J mice. 2. The decrease of GSH content with aging is markedly observed in SAM strains. 3. The oxidized glutathione (GSSG) content of eyes increased significantly with aging in SAM. 4. Ophthalmic changes, including cataract, increased with age in SAM alone. 5. The decrease of GSH content and the increase of GSH oxidation may be involved in the pathogenesis of cataract in SAM.

在加速衰老小鼠（SAM）和C57BL/J小鼠中研究了晶状体中谷胱甘肽（GSH）含量与年龄相关的变化。2. 在SAM品系中明显观察到GSH含量随衰老而降低。3. 在SAM中，眼睛的氧化型谷胱甘肽（GSSG）含量随衰老显著增加。4. 仅在SAM中，包括白内障在内的眼部变化随年龄增加。5. GSH含量的降低和GSH氧化的增加可能参与了SAM白内障的发病机制。

Teramoto S, Fukuchi Y, Uejima Y, Ito H, Orimo H

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.

Comp Biochem Physiol Comp Physiol. 1992 Aug;102(4):693-6.

Age-related changes in glutathione (GSH) content of eye lenses were investigated in senescence-accelerated mouse (SAM) and C57BL/J mice. 2. The decrease of GSH content with aging is markedly observed in SAM strains. 3. The oxidized glutathione (GSSG) content of eyes increased significantly with aging in SAM. 4. Ophthalmic changes, including cataract, increased with age in SAM alone. 5. The decrease of GSH content and the increase of GSH oxidation may be involved in the pathogenesis of cataract in SAM.

在加速衰老小鼠（SAM）和C57BL/J小鼠中研究了晶状体中谷胱甘肽（GSH）含量与年龄相关的变化。2. 在SAM品系中明显观察到GSH含量随衰老而降低。3. 在SAM中，眼睛的氧化型谷胱甘肽（GSSG）含量随衰老显著增加。4. 仅在SAM中，包括白内障在内的眼部变化随年龄增加。5. GSH含量的降低和GSH氧化的增加可能参与了SAM白内障的发病机制。