Barthe P, Gómez J R, Suárez C, Ferro S, Figueres B
Servicio de Otorrinolaringología, Hospital Central de Asturias, Universidad de Oviedo.
Acta Otorrinolaringol Esp. 1992 May-Jun;43(3):183-7.
Thirty four patients with allergic rhinitis were included in two randomized groups and treated with Cetirizine and Astemizole respectively, 10 mg/day in oral administration during 15 days. This study was designed in order to compare the efficacy and tolerance of Cetirizine versus Astemizole, with special reference on the collateral effects on the central nervous system. Although both drugs showed good results. Cetirizine had a statistically significant better outcome in the evolution of symptoms, above all at the second day of treatment. Also it showed superior results, based on a subjective approach, related to the rapidity, power and efficacy of its action.
34名过敏性鼻炎患者被纳入两个随机分组，分别接受西替利嗪和阿司咪唑治疗，口服剂量均为每日10毫克，持续15天。本研究旨在比较西替利嗪和阿司咪唑的疗效及耐受性，特别关注对中枢神经系统的副作用。尽管两种药物均显示出良好效果，但西替利嗪在症状改善方面具有统计学上的显著优势，尤其是在治疗的第二天。此外，从主观角度来看，西替利嗪在作用的快速性、强度和疗效方面也表现出更优的结果。
