Hou L, Shi D, Tu S M, Zhang H Z, Hung M C, Ling D
Department of Oral Pathology, Shangdong Medical University, Jinan, P.R. China.
Cancer Lett. 1992 Aug 31;65(3):215-20. doi: 10.1016/0304-3835(92)90234-m.
Monoclonal antibody PAb3 to c-erbB-2/neu protein was utilized in the immunoperoxidase staining of 86 human specimens from oral mucosa. These tissue specimens represented a spectrum from 7 normal to 9 simple hyperplasia, 15 mild dysplasia, 14 moderate dysplasia, 20 severe dysplasia and 21 squamous cell carcinoma. Our study indicated that as the cells acquire a more malignant phenotype, there was a progressive increase in neu expression. It also suggested that neu may be involved in the development of oral cancers and that its evaluation in the early stages may assist in the diagnosis and management of oral cancers.
针对c-erbB-2/neu蛋白的单克隆抗体PAb3用于86例口腔黏膜人体标本的免疫过氧化物酶染色。这些组织标本涵盖了从7例正常到9例单纯增生、15例轻度发育异常、14例中度发育异常、20例重度发育异常以及21例鳞状细胞癌的范围。我们的研究表明，随着细胞获得更具恶性的表型，neu表达呈渐进性增加。这也提示neu可能参与口腔癌的发生发展，并且在早期对其进行评估可能有助于口腔癌的诊断和治疗。
