绘制乙醇戒断期间激活的大鼠脑结构：谷氨酸和N-甲基-D-天冬氨酸受体的作用
Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors.
作者信息
Morgan P F, Nadi N S, Karanian J, Linnoila M
机构信息
Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
出版信息
Eur J Pharmacol. 1992 Mar 12;225(3):217-23. doi: 10.1016/0922-4106(92)90023-o.
Brain structures activated during ethanol withdrawal have been mapped by visualizing c-fos mRNA expression. The regional distribution of c-fos mRNA in brain during ethanol withdrawal can be mimicked by acute injection of N-methyl-D-aspartic acid (NMDA) and is stereospecifically blocked by the NMDA receptor antagonist, MK-801. The findings reveal that the dentate gyrus and piriform cortex are selectively activated during ethanol withdrawal and suggest that this may be mediated by glutamate activation of NMDA receptors.
通过可视化c-fos mRNA表达，已绘制出乙醇戒断期间激活的脑结构。急性注射N-甲基-D-天冬氨酸（NMDA）可模拟乙醇戒断期间大脑中c-fos mRNA的区域分布，且NMDA受体拮抗剂MK-801可立体特异性阻断这种分布。研究结果表明，齿状回和梨状皮质在乙醇戒断期间被选择性激活，提示这可能由NMDA受体的谷氨酸激活介导。
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