N-甲基-D-天冬氨酸拮抗剂可抑制对乙醇的快速耐受性。

NMDA antagonist inhibits rapid tolerance to ethanol.

作者信息

Khanna J M, Wu P H, Weiner J, Kalant H

机构信息

Department of Pharmacology, University of Toronto, Canada.

出版信息

Brain Res Bull. 1991 Apr;26(4):643-5. doi: 10.1016/0361-9230(91)90109-w.

DOI:10.1016/0361-9230(91)90109-w

PMID:1831064

Abstract

To test whether N-methyl-D-aspartate (NMDA) receptors have a role in the development of ethanol tolerance, (+)MK-801, an NMDA antagonist, and (-)MK-801, an inactive isomer, were tested in a rapid tolerance paradigm. Results showed that (+)MK-801 blocked the development of rapid tolerance to ethanol in the tilt-plane and hypothermia tests, while (-)MK-801 was ineffective. Neither drug changed the blood ethanol levels in the treated and untreated animals. These data suggest that the known role of NMDA receptors in long-term synaptic facilitation may underlie the effect of learning in the development of tolerance to the motor-impairing and hypothermic effects of ethanol.

摘要

为了测试N-甲基-D-天冬氨酸（NMDA）受体在乙醇耐受性发展中是否起作用，在快速耐受性范式中对NMDA拮抗剂（+）MK-801和无活性异构体（-）MK-801进行了测试。结果表明，在倾斜平面和体温过低测试中，（+）MK-801可阻止对乙醇快速耐受性的发展，而（-）MK-801则无效。两种药物均未改变治疗组和未治疗组动物的血液乙醇水平。这些数据表明，NMDA受体在长期突触易化中的已知作用可能是学习对乙醇运动损害和体温过低作用耐受性发展的基础。