Evans A T, Gordge P C, Sahni V, Evans F J
Department of Pharmacognosy, School of Pharmacy, London, UK.
J Pharm Pharmacol. 1992 Apr;44(4):361-3. doi: 10.1111/j.2042-7158.1992.tb03622.x.
Resiniferatoxin-induced erythema of mouse ear was shown to possess characteristics of both a phorbol ester-mediated response and that induced by the neurogenic irritant, capsaicin. Whereas the response to the phorbol ester, sapintoxin D, was delayed and prolonged, and was augmented by capsaicin pretreatment, the response to resiniferatoxin was biphasic, with the early phase being antagonized by capsaicin desensitization. However, resiniferatoxin was most potent in inducing a delayed erythema which, unlike the capsaicin response, was sensitive to inhibition by low dose hydrocortisone treatment, but not to chronic capsaicin desensitization. It is concluded that the erythema response to resiniferatoxin has a mixed aetiology, which may explain the unique potency of this toxin.
研究表明，树脂毒素诱导的小鼠耳部红斑具有佛波酯介导反应和神经源性刺激物辣椒素诱导反应的特征。对佛波酯沙平毒素D的反应延迟且持续时间长，辣椒素预处理可增强该反应，而对树脂毒素的反应是双相的，早期阶段可被辣椒素脱敏所拮抗。然而，树脂毒素在诱导延迟性红斑方面最为有效，与辣椒素反应不同的是，该延迟性红斑对低剂量氢化可的松治疗的抑制敏感，但对慢性辣椒素脱敏不敏感。结论是，对树脂毒素的红斑反应具有混合病因，这可能解释了该毒素独特的效力。
